Reactivity of oximes for diverse methodologies and synthetic applications

Oximes are valuable synthetic building blocks with reactivity modes that enable their use in diverse methodologies, from cycloadditions to bioconjugation. Their towards photocatalysis and transition metals makes them ideal starting materials for N-containing heterocycles, amino alcohols amines. Developments oxime since 2016 have enabled transformations such as the addition of iminyl radicals alkenes generate functionalized imines, [2 + 2]-cycloadditions access azetidines. The unique properties imparted by N–O bond also been used integrate dynamic chemistries into materials. In this Review, we discuss innovative powerful functional group, a focus on fragmentation cycloadditions, along applications including materials, energetic biocatalytic reductions. We conclude highlighting methodologies based challenges using oximes applications, offer insight future directions these areas. motifs reactivity. This Review outlines breadth through metal catalysis photocatalysis, 2]-cycloaddition reactions, asymmetric reduction science. highlight blocks.